College Football Picks
Northwestern vs Indiana College Football Picks, Odds & Prediction for Friday
Indiana is laying more than three touchdowns as the defending Big Ten champion. Joe Jensen takes Northwestern to cover the spread at Memorial Stadium, with Cignetti’s disciplined coaching approach and Northwestern’s competent offense driving the play.
Missouri vs Mississippi State College Football Picks, Odds & Prediction for Saturday
Missouri is ranked #19, three spots higher than #24 Mississippi State, but they’re a 6-point underdog on the road. Joe Jensen takes the Tigers to cover with multiple prediction models projecting a Missouri win.
RBD’s Navy vs UAB Pick: Friday Night Total Play for the Blazers
RBD flips his Navy at UAB pick from Under to Over, backed by the strong Friday night Over trend running 10-4 (71%) through three weeks of college football.
Texas A&M vs LSU College Football Picks, Odds & Prediction for Saturday
Marcel Reed has beaten LSU in back-to-back years. Joe Jensen takes Texas A&M to cover the 9-point spread at Tiger Stadium, with the line movement and Reed’s specific matchup edge driving the play.
Oregon vs USC College Football Picks, Odds & Prediction for Saturday
USC is 4-0 straight up but 1-3 against the spread. Joe Jensen takes Oregon to cover the 2.5-point spread at the Coliseum, with the Trojans’ defensive weaknesses and Oregon’s 4-game win streak in this rivalry driving the play.
South Carolina vs Alabama College Football Picks, Odds & Prediction for Saturday
LaNorris Sellers has kept games close vs Alabama the last two years (2-point loss in 2024, 7-point loss in 2025). Joe Jensen takes South Carolina to cover the 12.5-point spread at Bryant-Denny Stadium.
Central Michigan vs Miami College Football Picks, Odds & Prediction for Saturday
Miami is laying more than 41 points at home while looking ahead to their October 3 matchup with Florida State. Joe Jensen takes Central Michigan to cover the spread at Hard Rock Stadium.
Wisconsin vs Penn State College Football Picks, Odds & Prediction for Saturday
Wisconsin lost 41-13 to Notre Dame in their season opener while Penn State has allowed just 9 total points through two games. Joe Jensen takes the Nittany Lions to cover the 10.5-point spread at Beaver Stadium.
Ole Miss vs Florida College Football Picks, Odds & Prediction for Saturday
The line has moved 5 points toward Florida since opening. Joe Jensen takes Ole Miss to cover the 3.5-point spread at The Swamp, with the Rebels’ signature win over LSU driving the play.
Oklahoma vs Georgia College Football Picks, Odds & Prediction for Saturday
Oklahoma’s defense ranks fourth nationally in yards per play allowed. Joe Jensen takes the Sooners to cover the 13.5-point spread at Sanford Stadium, with the elite defensive matchup and Smart’s conservative coaching approach driving the play.
Iowa vs Michigan College Football Picks, Odds & Prediction for Saturday
Both teams have elite defenses and limited offenses. Joe Jensen takes Iowa to cover the 4.5-point spread at Michigan Stadium, with Kirk Ferentz’s Big Ten profile driving the play.
Iowa State vs Utah College Football Picks, Odds & Prediction for Saturday
Iowa State beat Utah 31-28 at Rice-Eccles Stadium just two years ago. Joe Jensen takes the Cyclones to cover the 9.5-point spread in Salt Lake City.
Texas vs Tennessee College Football Picks, Odds & Prediction for Saturday
The line has moved from Texas -7 at open down to -5.5 currently. Joe Jensen takes Tennessee to cover at Neyland Stadium in one of the biggest SEC matchups of the year.
Sam Houston vs Texas Tech College Football Picks, Odds & Prediction for Saturday
Texas Tech is laying nearly five touchdowns coming off a signature win over Houston. Joe Jensen takes Sam Houston to cover the spread at Galaxy Stadium, with Texas Tech’s Big 12 focus and predictable coaching approach driving the play.
Wake Forest vs Louisville College Football Picks, Odds & Prediction for Saturday
The underdog is 9-0 against the spread in the last 9 meetings between these two teams. Joe Jensen takes Wake Forest to cover the 12.5-point spread at L&N Federal Credit Union Stadium.
Illinois vs Ohio State College Football Picks, Odds & Prediction for Saturday
Ohio State is laying nearly four touchdowns in the Battle for the Illibuck. Joe Jensen takes Illinois to cover the 27.5-point spread at Ohio Stadium, with last year’s 18-point margin and Day’s game management approach driving the play.
NCAA Football Betting Guide
New to college football betting or football wagering in general? Point spreads and odds can be confusing at first glance! We explain how these wagers work, as well as totals, futures and prop bets in our How to Bet on College Football article!
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